最佳解决方案
/// <summary> /// 会产生graphics异常的PixelFormat /// </summary> private static PixelFormat[] indexedPixelFormats = { PixelFormat.Undefined, PixelFormat.DontCare, PixelFormat.Format16bppArgb1555, PixelFormat.Format1bppIndexed, PixelFormat.Format4bppIndexed, PixelFormat.Format8bppIndexed }; /// <summary> /// 判断图片的PixelFormat 是否在 引发异常的 PixelFormat 之中 /// </summary> /// <param name="imgPixelFormat">原图片的PixelFormat</param> /// <returns></returns> private static bool IsPixelFormatIndexed(PixelFormat imgPixelFormat) { foreach (PixelFormat pf in indexedPixelFormats) { if (pf.Equals(imgPixelFormat)) return true; } return false; } if (IsPixelFormatIndexed(sBitmap.PixelFormat)) { Bitmap bmp = new Bitmap(sBitmap.Width, sBitmap.Height, PixelFormat.Format32bppArgb); using (Graphics g = Graphics.FromImage(bmp)) { g.InterpolationMode = System.Drawing.Drawing2D.InterpolationMode.HighQualityBicubic; g.SmoothingMode = System.Drawing.Drawing2D.SmoothingMode.HighQuality; g.CompositingQuality = System.Drawing.Drawing2D.CompositingQuality.HighQuality; g.DrawImage(sBitmap, 0, 0); } sBitmap = bmp; } Graphics graphics = Graphics.FromImage(sBitmap);可以采用将此图片先clone到一张BMP上的方法来解决